Multiple Choice
In the overview of DNA replication, what is the primary function of helicase?
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8. DNA Replication
Overview of DNA Replication
Multiple Choice
In eukaryotic DNA replication, what is the first major step that initiates replication at an origin?
A
Joining of Okazaki fragments by DNA ligase on the lagging strand
B
Removal of RNA primers and replacement with DNA by DNA polymerase
C
Resolution of supercoils ahead of the replication fork by DNA ligase
D
Binding of the origin recognition complex (ORC) to replication origins to begin assembling the pre-replication complex
Verified step by step guidance1
Understand that eukaryotic DNA replication begins at specific sites called origins of replication, where the process is carefully regulated.
Recognize that the first major step involves the identification and binding of specific proteins to these origins to mark the starting point for replication.
Learn that the Origin Recognition Complex (ORC) is a multi-protein complex that binds directly to the replication origins, serving as a platform for assembling other necessary factors.
Know that after ORC binding, additional proteins are recruited to form the pre-replication complex (pre-RC), which prepares the DNA for unwinding and synthesis.
Distinguish this initial step from later steps such as joining Okazaki fragments, primer removal, or resolving supercoils, which occur downstream during the elongation phase of replication.
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