Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

17. Mutation, Repair, and Recombination

DNA Repair

Genetics

17. Mutation, Repair, and Recombination

DNA Repair

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Multiple Choice

Which is the most efficient cellular mechanism to prevent DNA mutations caused by UV radiation?

Homologous recombination

Nucleotide excision repair

Mismatch repair

Base excision repair

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Verified step by step guidance

Understand that UV radiation primarily causes DNA damage by inducing the formation of thymine dimers, which are covalent linkages between adjacent thymine bases in DNA.

Recognize that different DNA repair mechanisms specialize in fixing different types of DNA damage: for example, mismatch repair corrects replication errors, base excision repair fixes small base modifications, and homologous recombination repairs double-strand breaks.

Identify that nucleotide excision repair (NER) is the cellular mechanism specifically designed to recognize and remove bulky DNA lesions such as thymine dimers caused by UV radiation.

Recall the general process of nucleotide excision repair: damage recognition, excision of a short single-stranded DNA segment containing the lesion, DNA synthesis to fill the gap, and ligation to restore the DNA strand.

Conclude that because NER directly targets and removes UV-induced bulky lesions, it is the most efficient mechanism to prevent mutations caused by UV radiation.