Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

17. Mutation, Repair, and Recombination

DNA Repair

Genetics

17. Mutation, Repair, and Recombination

DNA Repair

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Multiple Choice

Which of the following mechanisms contributes directly to the fidelity of DNA replication?

Alternative splicing of mRNA

Telomerase activity

Mismatch repair system

Proofreading activity of DNA polymerase

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Verified step by step guidance

Understand that fidelity of DNA replication refers to the accuracy with which DNA polymerase copies the DNA template, minimizing errors during replication.

Review the mechanisms listed: Alternative splicing of mRNA affects RNA processing, not DNA replication accuracy; Telomerase activity extends chromosome ends but does not directly correct replication errors.

Focus on the mismatch repair system, which corrects errors after replication, thus contributing indirectly to fidelity but not during the replication process itself.

Recognize that proofreading activity of DNA polymerase is a built-in function where the enzyme checks and corrects mismatched nucleotides immediately during DNA synthesis, directly enhancing replication fidelity.

Conclude that the mechanism contributing directly to replication fidelity is the proofreading activity of DNA polymerase because it acts in real-time to prevent errors from being incorporated.