Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

8. DNA Replication

Overview of DNA Replication

Genetics

8. DNA Replication

Overview of DNA Replication

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Multiple Choice

What would happen to DNA replication in DNA polymerase lost its 3' to 5' exonuclease activity?

Replication would speed up

Proofreading would stop and replication would stall

Replication would only occur on the leading strand

Replication would only occur on the lagging strand

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Verified step by step guidance

Understand the role of DNA polymerase: DNA polymerase is responsible for synthesizing new DNA strands by adding nucleotides to a pre-existing chain during DNA replication.

Recognize the importance of 3' to 5' exonuclease activity: This activity is crucial for proofreading, allowing DNA polymerase to remove incorrectly paired nucleotides and replace them with the correct ones, ensuring high fidelity in DNA replication.

Consider the impact of losing 3' to 5' exonuclease activity: Without this proofreading ability, DNA polymerase would be unable to correct errors, leading to an accumulation of mutations.

Analyze the consequences on replication: The lack of error correction would likely cause replication to stall, as the accumulation of errors could disrupt the replication process and lead to instability in the newly synthesized DNA.

Conclude the effect on DNA replication: The absence of 3' to 5' exonuclease activity would not affect the speed of replication directly but would compromise the accuracy, potentially stalling replication due to uncorrected errors.