Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
9. Mitosis and Meiosis
Meiosis
Problem 29
Textbook Question
Consider a diploid cell that contains three pairs of chromosomes designated AA, BB, and CC. Each pair contains a maternal and a paternal member (e.g., Am and Ap). Using these designations, demonstrate your understanding of mitosis and meiosis by drawing chromatid combinations as requested. Be sure to indicate when chromatids are paired as a result of replication and/or synapsis.
Assume that during meiosis I none of the C chromosomes disjoin at metaphase, but they separate into dyads (instead of monads) during meiosis II. How would this change the alignments that you constructed during the anaphase stages in meiosis I and II? Draw them.

1
Understand the problem: The question involves a diploid cell with three pairs of chromosomes (AA, BB, CC), where each pair has a maternal and paternal member. The focus is on meiosis and the specific scenario where the C chromosomes fail to disjoin at metaphase of meiosis I but separate into dyads during meiosis II. This affects the chromatid alignments during anaphase stages of meiosis I and II.
Step 1: Recall the normal process of meiosis. In meiosis I, homologous chromosomes (e.g., A^m and A^p) pair up and segregate into two daughter cells. In meiosis II, the sister chromatids of each chromosome separate into monads. This process ensures that each gamete receives one copy of each chromosome.
Step 2: Analyze the non-disjunction event. In this case, the C chromosomes fail to disjoin during metaphase of meiosis I. This means that both the maternal and paternal C chromosomes (C^m and C^p) will move together to one pole during anaphase I, instead of separating into different cells. This results in one daughter cell having both C chromosomes and the other having none.
Step 3: Consider the impact on meiosis II. During meiosis II, the sister chromatids of the C chromosomes in the affected daughter cell will separate into dyads (not monads, as is typical). This means that the gametes produced from this cell will have an abnormal number of C chromatids. The other daughter cell from meiosis I, which lacks C chromosomes, will produce gametes without any C chromatids.
Step 4: Visualize the alignments. For anaphase I, show the A and B chromosomes segregating normally, while both C^m and C^p move to the same pole. For anaphase II, show the sister chromatids of the C chromosomes separating into dyads in the affected cell, while the other cell lacks C chromosomes entirely. Use diagrams to clearly depict these alignments and label each chromatid (e.g., A^m, A^p, C^m, C^p).

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Mitosis
Mitosis is the process of cell division that results in two genetically identical daughter cells, each with the same number of chromosomes as the original cell. It involves several stages: prophase, metaphase, anaphase, and telophase, where chromosomes are replicated and evenly distributed. Understanding mitosis is crucial for recognizing how cells replicate and maintain genetic consistency across generations.
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Mitosis Steps
Meiosis
Meiosis is a specialized form of cell division that reduces the chromosome number by half, resulting in four genetically diverse gametes. It consists of two rounds of division: meiosis I, where homologous chromosomes separate, and meiosis II, where sister chromatids separate. This process is essential for sexual reproduction and introduces genetic variation through independent assortment and crossing over.
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Chromatid Pairing and Separation
Chromatid pairing occurs during the S phase of the cell cycle when DNA is replicated, resulting in sister chromatids that are joined at the centromere. In meiosis, the alignment and separation of these chromatids during anaphase are critical for ensuring proper distribution of genetic material. The scenario described, where C chromosomes do not disjoin during meiosis I, affects the expected outcomes in anaphase, leading to unique chromatid combinations in the resulting gametes.
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Chromatin
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Textbook Question
A diploid cell contains three pairs of homologous chromosomes designated C1 and C2, M1 and M2, and S1 and S2. No crossing over occurs. What combinations of chromosomes are possible in (a) daughter cells following mitosis, (b) cells undergoing the first meiotic metaphase, (c) haploid cells following both divisions of meiosis?
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