Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

2. Mendel's Laws of Inheritance

Pedigrees

Genetics

2. Mendel's Laws of Inheritance

Pedigrees

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2:03 minutes

Problem A.1b

Textbook Question

Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.
A person who on the basis of family history must be a heterozygous carrier of a recessive mutant allele

Verified step by step guidance

Step 1: Understand the term 'obligate carrier'. An obligate carrier is an individual who, based on their family history, must carry a specific genetic mutation. This is often determined by patterns of inheritance in the family, such as autosomal recessive inheritance.

Step 2: Analyze the statement provided in the problem. The statement describes a person who, due to their family history, must be a heterozygous carrier of a recessive mutant allele. This matches the definition of an obligate carrier.

Step 3: Review the list of possible answers provided in the problem: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%. Identify which term aligns with the description in the statement.

Step 4: Match the term 'obligate carrier' to the statement, as it is the best fit based on the definition and the context provided.

Step 5: Confirm your understanding by revisiting the concept of obligate carriers and ensuring that the family history aspect aligns with the genetic inheritance patterns described in the problem.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Heterozygous Carrier

A heterozygous carrier is an individual who possesses two different alleles for a particular gene, one of which may be a recessive mutant allele. In the context of genetic disorders, this means the person does not express the disorder but can pass the recessive allele to their offspring. Understanding this concept is crucial for interpreting family histories and predicting inheritance patterns.

Recessive Mutant Allele

A recessive mutant allele is a variant of a gene that does not manifest its effects in the presence of a dominant allele. For an individual to express a trait associated with a recessive allele, they must inherit two copies of that allele, one from each parent. This concept is fundamental in genetics, particularly in understanding how traits are inherited and the likelihood of offspring being affected by genetic conditions.

Obligate Carrier

An obligate carrier is an individual who must carry a specific allele due to their family history, even if they do not express the associated trait. In the case of recessive disorders, if both parents are carriers, their child has a 25% chance of being affected, a 50% chance of being a carrier, and a 25% chance of being unaffected. Recognizing obligate carriers is essential for genetic counseling and risk assessment in families.

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