Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
4. Genetic Mapping and Linkage
Crossing Over and Recombinants
Problem 13
Textbook Question
Two different female Drosophila were isolated, each heterozygous for the autosomally linked genes b (black body), d (dachs tarsus), and c (curved wings). These genes are in the order d–b–c, with b being closer to d than to c. Shown here is the genotypic arrangement for each female along with the various gametes formed by both:

Identify which categories are noncrossovers (NCOs), single crossovers (SCOs), and double crossovers (DCOs) in each case. Then, indicate the relative frequency in which each will be produced.

1
Step 1: Understand the genetic arrangement and linkage. The genes d, b, and c are autosomally linked, meaning they are located on the same chromosome. The order of the genes is d–b–c, with b being closer to d than to c. This arrangement affects the likelihood of crossover events during meiosis.
Step 2: Define the categories of gametes. Noncrossovers (NCOs) are gametes that retain the parental arrangement of alleles without any recombination. Single crossovers (SCOs) occur when recombination happens between two adjacent genes (e.g., d and b or b and c). Double crossovers (DCOs) occur when recombination happens between both pairs of adjacent genes (d and b, and b and c).
Step 3: Analyze the genotypic arrangement for each female. For each female, identify the parental (noncrossover) arrangement of alleles. Then, determine which gametes result from single crossover events and which result from double crossover events based on the recombination patterns.
Step 4: Predict the relative frequencies of each category. Noncrossovers (NCOs) are typically the most frequent because recombination is less likely to occur. Single crossovers (SCOs) are less frequent than NCOs but more frequent than double crossovers (DCOs). Double crossovers (DCOs) are the least frequent because they require two independent recombination events.
Step 5: Use the genetic distances between the genes to refine frequency predictions. The closer two genes are on the chromosome (e.g., d and b), the less likely recombination will occur between them. Conversely, genes that are farther apart (e.g., d and c) have a higher likelihood of recombination. This information can help estimate the relative frequencies of SCOs and DCOs.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Genetic Linkage
Genetic linkage refers to the tendency of genes located close to each other on a chromosome to be inherited together during meiosis. This phenomenon affects the assortment of alleles and can lead to nonrandom combinations of traits in offspring. Understanding linkage is crucial for predicting gamete formation and the inheritance patterns of linked genes.
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Types of Crossovers
Crossovers occur during meiosis when homologous chromosomes exchange genetic material. Noncrossovers (NCOs) result in gametes that are identical to the parental types, while single crossovers (SCOs) produce gametes with a mix of parental and recombinant alleles. Double crossovers (DCOs) involve two crossover events and can further shuffle genetic material, leading to more complex combinations of alleles.
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Recombination Frequency
Recombination frequency is a measure of how often crossovers occur between two genes during meiosis, influencing the genetic map distance between them. It is calculated based on the proportion of recombinant gametes produced compared to the total number of gametes. This frequency helps in predicting the likelihood of NCOs, SCOs, and DCOs, which is essential for understanding genetic variation in offspring.
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Textbook Question
What is the proposed basis for positive interference?
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