Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

17. Mutation, Repair, and Recombination

Induced Mutations

Genetics

17. Mutation, Repair, and Recombination

Induced Mutations

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Multiple Choice

Which of the following mutations would have the least effect on an individual?

4 base pair insertion in an intron

Deletion of an exon

A nonsense mutation in the last exon of a gene

A point mutation in the splice site of an intron

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Verified step by step guidance

Understand the role of introns and exons in gene expression. Introns are non-coding regions that are removed during RNA splicing, while exons are coding regions that are expressed in the final protein.

Consider the impact of a 4 base pair insertion in an intron. Since introns are removed during RNA processing, small insertions in introns often have minimal impact on the final protein product.

Evaluate the effect of a deletion of an exon. Exons are crucial for coding the protein, so their deletion can lead to a loss of important protein-coding information, potentially resulting in a nonfunctional protein.

Analyze the consequences of a nonsense mutation in the last exon of a gene. A nonsense mutation introduces a premature stop codon, which can truncate the protein. However, if it occurs in the last exon, the impact might be less severe as the majority of the protein is already synthesized.

Examine the effect of a point mutation in the splice site of an intron. Splice sites are critical for proper RNA splicing. A mutation here can lead to incorrect splicing, potentially resulting in a dysfunctional protein.