The Rh blood group in humans is determined by a gene on chromosome 1. A dominant allele produces Rh+ blood type, and a recessive allele generates Rh-. Elliptocytosis is an autosomal dominant disorder that produces abnormally shaped red blood cells that have a short life span resulting in hereditary anemia. A large family with elliptocytosis is tested for genetic linkage of Rh blood group and the disease. The lod score data below are obtained for the family.

What is Zₘₐₓ for this family? 

In Drosophila, Dichaete (D) is a mutation on chromosome III with a dominant effect on wing shape. It is lethal when homozygous. The genes ebony body (e) and pink eye (p) are recessive mutations on chromosome III. Flies from a Dichaete stock were crossed to homozygous ebony, pink flies, and the F₁ progeny, with a Dichaete phenotype, were backcrossed to the ebony, pink homozygotes. Using the results of this backcross shown in the table,

What is the sequence and interlocus distance between these three genes?

The table given here lists the arrangement of alleles of linked genes in dihybrid organisms, the recombination frequency between the genes, and specific gamete genotypes. Using the information provided, determine the expected frequency of the listed gametes. Assume one map unit equals 1% recombination and, when three genes are involved, interference is zero.

Drosophila females homozygous for the third chromosomal genes pink and ebony (the same genes from Problem 16) were crossed with males homozygous for the second chromosomal gene dumpy. Because these genes are recessive, all offspring were wild type (normal). F₁ females were testcrossed to triply recessive males. If we assume that the two linked genes, pink and ebony, are 20 mu apart, predict the results of this cross. If the reciprocal cross were made (F₁ males—where no crossing over occurs—with triply recessive females), how would the results vary, if at all?

The Rh blood group in humans is determined by a gene on chromosome 1. A dominant allele produces Rh+ blood type, and a recessive allele generates Rh-. Elliptocytosis is an autosomal dominant disorder that produces abnormally shaped red blood cells that have a short life span resulting in hereditary anemia. A large family with elliptocytosis is tested for genetic linkage of Rh blood group and the disease. The lod score data below are obtained for the family.

Over what range of θ do lod scores indicate significant evidence in favor of genetic linkage?

The Rh blood group in humans is determined by a gene on chromosome 1. A dominant allele produces Rh+ blood type, and a recessive allele generates Rh-. Elliptocytosis is an autosomal dominant disorder that produces abnormally shaped red blood cells that have a short life span resulting in hereditary anemia. A large family with elliptocytosis is tested for genetic linkage of Rh blood group and the disease. The lod score data below are obtained for the family.

From these data, can you conclude that Rh and elliptocytosis loci are genetically linked in this family? Why or why not?

Genetic linkage mapping for a large number of families identifies 4% recombination between the genes for Rh blood type and elliptocytosis (see Problem 18). At the Rh locus, alleles R and r control Rh+ and Rh- blood types. Allele E producing elliptocytosis is dominant to the wild-type recessive allele e. Tom and Terri each have elliptocytosis, and each is . Tom's mother has elliptocytosis and is Rh- while his father is healthy and has Rh+. Terri's father is Rh+ and has elliptocytosis; Terri's mother is Rh- and is healthy.

What is the probability that a child of Tom and Terri who is Rh+ will have elliptocytosis?

Genetic linkage mapping for a large number of families identifies 4% recombination between the genes for Rh blood type and elliptocytosis (see Problem 18). At the Rh locus, alleles R and r control Rh+ and Rh- blood types. Allele E producing elliptocytosis is dominant to the wild-type recessive allele e. Tom and Terri each have elliptocytosis, and each is . Tom's mother has elliptocytosis and is Rh- while his father is healthy and has Rh+. Terri's father is Rh+ and has elliptocytosis; Terri's mother is Rh- and is healthy.

What is the probability that the first child of Tom and Terri will be Rh− and have elliptocytosis?

A group of families in which an autosomal dominant condition is present are studied to determine lod scores for possible genetic linkage between three RFLP markers (R1, R2, and R3) and the disease gene. The chart shows lod scores at each of the recombination distances (θ values) tested. Provide an interpretation of the lod score results for each RFLP. Be specific about any significant evidence of genetic linkage.