In Drosophila, gray body color is dominant to ebony body color, while long wings are dominant to vestigial wings. Assuming that the P₁ individuals are homozygous, work the following crosses through the F₂ generation, and determine the genotypic and phenotypic ratios for each generation. gray, long x gray, and vestigial.
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
2. Mendel's Laws of Inheritance
Dihybrid Cross
Problem 15
Textbook Question
In a study of black guinea pigs and white guinea pigs, 100 black animals were crossed with 100 white animals, and each cross was carried to an F₂ generation. In 94 of the crosses, all the F₁ offspring were black and an F₂ ratio of 3 black:1 white was obtained. In the other 6 cases, half of the F₁ animals were black and the other half were white. Why? Predict the results of crossing the black and white F₁ guinea pigs from the 6 exceptional cases.

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Step 1: Understand the genetic basis of coat color in guinea pigs. Typically, black and white coat colors can be determined by alleles at a single gene locus, where black (B) is dominant over white (b). This means that black guinea pigs can be either homozygous dominant (BB) or heterozygous (Bb), while white guinea pigs are homozygous recessive (bb).
Step 2: Analyze the first group of crosses (94 cases) where all F₁ offspring were black and the F₂ generation showed a 3 black : 1 white ratio. This suggests that the black parents were homozygous dominant (BB) crossed with homozygous recessive (bb), producing all heterozygous black F₁ offspring (Bb). When these F₁ individuals are crossed (Bb × Bb), the F₂ generation exhibits the classic Mendelian 3:1 phenotypic ratio.
Step 3: Examine the exceptional 6 cases where the F₁ generation had a 1:1 ratio of black to white offspring. This indicates that the black parent in these crosses was heterozygous (Bb) rather than homozygous (BB). Crossing a heterozygous black (Bb) with a white (bb) results in F₁ offspring that are half black (Bb) and half white (bb).
Step 4: Predict the results of crossing the black and white F₁ guinea pigs from the exceptional cases. Since the black F₁ guinea pigs are heterozygous (Bb) and the white F₁ guinea pigs are homozygous recessive (bb), crossing Bb × bb will produce offspring with a 1:1 ratio of black (Bb) to white (bb) guinea pigs.
Step 5: Summarize the genetic explanation: The difference in F₁ ratios between the two groups is due to the genotype of the black parent in the original cross—homozygous dominant (BB) in the majority of cases and heterozygous (Bb) in the exceptional cases—leading to different F₁ and F₂ phenotypic ratios.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Mendelian Inheritance and Dominance
Mendelian inheritance explains how traits are passed from parents to offspring through dominant and recessive alleles. A dominant allele masks the expression of a recessive allele in heterozygotes, resulting in a 3:1 phenotypic ratio in the F₂ generation when two heterozygotes are crossed.
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Variations on Dominance
Genotype and Phenotype Ratios in F₁ and F₂ Generations
The F₁ generation results from crossing two pure-breeding parents, typically showing uniform phenotype if one allele is dominant. The F₂ generation, from crossing F₁ individuals, reveals genotype and phenotype ratios (e.g., 3:1) that help identify dominant and recessive traits and heterozygosity.
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F Factor and Hfr
Genetic Explanation for Deviations in Expected Ratios
When F₁ offspring show a 1:1 black to white ratio instead of all black, it suggests one parent was heterozygous or the trait is controlled by multiple alleles or loci. Predicting crosses in these cases involves understanding heterozygous crosses and possible genotypes to determine expected offspring ratios.
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Genetics of Development
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