In Drosophila, gray body color is dominant to ebony body color, while long wings are dominant to vestigial wings. Assuming that the P₁ individuals are homozygous, work the following crosses through the F₂ generation, and determine the genotypic and phenotypic ratios for each generation. gray, long x ebony, vestigial
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
2. Mendel's Laws of Inheritance
Dihybrid Cross
Problem 16a
Textbook Question
Pigment in mouse fur is only produced when the C allele is present. Individuals of the cc genotype are white. If color is present, it may be determined by the A, a alleles. AA or Aa results in agouti color, while aa results in black coats. What F₁ and F₂ genotypic and phenotypic ratios are obtained from a cross between AACC and aacc mice?

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Step 1: Identify the genotypes of the parent mice. The first parent is AACC (homozygous dominant for both traits), and the second parent is aacc (homozygous recessive for both traits).
Step 2: Determine the gametes produced by each parent. The AACC parent can only produce AC gametes, while the aacc parent can only produce ac gametes.
Step 3: Perform the F₁ cross by combining the gametes from both parents. Each offspring in the F₁ generation will inherit one allele from each parent, resulting in the genotype AaCc for all F₁ individuals.
Step 4: Determine the phenotypes of the F₁ generation. Since all F₁ individuals are AaCc, they will have the dominant C allele (allowing pigment production) and at least one dominant A allele (resulting in agouti fur). Thus, all F₁ individuals will have agouti fur.
Step 5: Perform the F₂ cross by self-crossing the F₁ individuals (AaCc × AaCc). Use a Punnett square to determine the genotypic and phenotypic ratios in the F₂ generation. For the genotypes, consider the independent assortment of the A/a and C/c alleles. For the phenotypes, remember that cc results in white fur (regardless of A/a alleles), Aa or AA with C results in agouti fur, and aa with C results in black fur.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Alleles and Genotypes
Alleles are different forms of a gene that can exist at a specific locus on a chromosome. In this context, the C allele is necessary for pigment production, while the A and a alleles determine the color of the fur. The genotype refers to the genetic makeup of an organism, such as AACC or aacc, which influences the phenotype, or observable traits.
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Punnett Square
A Punnett square is a diagram used to predict the genotypic and phenotypic ratios of offspring from a genetic cross. By organizing the alleles of the parents, it allows for a visual representation of all possible combinations in the offspring. This tool is essential for determining the expected ratios of genotypes and phenotypes in the F₁ and F₂ generations.
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Phenotypic Ratios
Phenotypic ratios describe the relative frequencies of different phenotypes in the offspring resulting from a genetic cross. In this case, the phenotypes are determined by the presence of the C allele and the combinations of A and a alleles. Understanding these ratios helps predict the appearance of the offspring based on their genotypes.
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