Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
4. Genetic Mapping and Linkage
Mapping Overview
Problem 1d
Textbook Question
How do we know that sister chromatids undergo recombination during mitosis?

1
Understand the concept of recombination: Recombination refers to the exchange of genetic material between homologous chromosomes or sister chromatids. During mitosis, sister chromatids are identical copies of a chromosome, and recombination can occur between them under certain circumstances.
Review experimental evidence: Scientists have observed recombination during mitosis through experiments involving genetic markers. For example, using cells with distinguishable genetic markers on sister chromatids, researchers can track changes in the genetic composition after mitosis.
Examine the role of DNA repair mechanisms: Recombination during mitosis is often associated with DNA repair processes, such as homologous recombination. When DNA damage occurs, sister chromatids can exchange genetic material to repair the damage, providing evidence of recombination.
Analyze the outcomes of mitotic recombination: Mitotic recombination can lead to observable genetic changes, such as loss of heterozygosity or the appearance of new genetic combinations. These outcomes can be studied in laboratory experiments to confirm recombination events.
Consider the use of molecular techniques: Techniques such as fluorescence microscopy and DNA sequencing have been used to directly observe recombination events during mitosis. These methods provide visual and molecular evidence of sister chromatid recombination.

This video solution was recommended by our tutors as helpful for the problem above
Video duration:
2mPlay a video:
Was this helpful?
Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Sister Chromatids
Sister chromatids are identical copies of a single chromosome that are connected by a centromere. They are formed during DNA replication in the S phase of the cell cycle and are crucial for ensuring that each daughter cell receives an identical set of chromosomes during cell division. Understanding their structure and behavior is essential for analyzing genetic recombination events.
Recommended video:
Guided course
Chromatin
Recombination
Recombination is the process by which genetic material is exchanged between homologous chromosomes during meiosis, leading to genetic diversity. While sister chromatids typically do not undergo recombination during mitosis, understanding the mechanisms of recombination in meiosis helps clarify the differences in chromosomal behavior during these two types of cell division.
Recommended video:
Guided course
Recombination after Single Strand Breaks
Chromosomal Mapping
Chromosomal mapping involves determining the relative positions of genes on a chromosome and understanding how they are inherited. Techniques such as genetic linkage analysis and the study of recombination frequencies provide insights into the physical arrangement of genes, which is essential for interpreting how sister chromatids behave during cell division and the implications for genetic variation.
Recommended video:
Guided course
Mapping with Markers
Related Videos
Related Practice
Multiple Choice
A map distance of 23.6 between two genes indicates which of the following?
3
views