Multiple Choice
In the context of cancer mutations, what is a tumor suppressor gene?
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19. Cancer Genetics
Cancer Mutations
Multiple Choice
Which of the following proteins is an example of a tumor suppressor?
A
Ras GTPase
B
HPV E6 protein
C
p53 transcription factor
Verified step by step guidance1
Understand the role of tumor suppressor proteins: Tumor suppressor proteins are crucial in regulating cell division, repairing DNA mistakes, and ensuring cells do not proliferate uncontrollably.
Identify the function of p53: The p53 transcription factor is a well-known tumor suppressor that plays a key role in preventing cancer formation by inducing cell cycle arrest, apoptosis, or senescence in response to DNA damage.
Differentiate between oncogenes and tumor suppressors: Oncogenes, like Ras GTPase, promote cell division and survival, whereas tumor suppressors, like p53, inhibit these processes to prevent tumor development.
Examine the role of HPV E6 protein: HPV E6 protein is not a tumor suppressor; it is an oncogenic protein that can degrade p53, thereby promoting cancer progression.
Conclude with the identification: Based on the functions and roles, p53 is the correct example of a tumor suppressor protein among the options provided.
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