A woman, S.R., had a maternal grandfather with hemophilia A (OMIM 306700), an X-linked recessive condition that reduces blood clotting. S.R.'s maternal grandmother and paternal grandparents are free of the condition, as are her partner, his parents, and his grandparents. S.R. has no siblings. She wants to know the chance that a son of hers will have the condition. What is that probability?
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
2. Mendel's Laws of Inheritance
Probability and Genetics
Problem 6b
Textbook Question
Consider the cross AaBbCC × AABbCc.
Use a Punnett square to predict the expected ratio of offspring phenotypes.

1
Step 1: Identify the genotypes of the parents. Parent 1 has the genotype AaBbCC, and Parent 2 has the genotype AABbCc. Each gene pair represents alleles for a specific trait.
Step 2: Determine the possible gametes for each parent. For Parent 1 (AaBbCC), the possible gametes are ABC, AbC, aBC, and abC. For Parent 2 (AABbCc), the possible gametes are ABC, ABc, AbC, and Abc.
Step 3: Construct a Punnett square. Create a grid where the rows represent the gametes of Parent 1 and the columns represent the gametes of Parent 2. Fill in each cell with the combination of alleles from the corresponding row and column.
Step 4: Analyze the offspring genotypes in the Punnett square. For each cell, determine the genotype of the offspring by combining the alleles from the gametes. For example, a cell might contain AaBbCc.
Step 5: Predict the phenotypic ratios. Based on the dominance and recessiveness of the alleles, determine the phenotype for each genotype. Count the occurrences of each phenotype in the Punnett square to calculate the expected ratio of offspring phenotypes.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Punnett Square
A Punnett square is a diagram used to predict the genotypes of offspring from a genetic cross. It organizes the possible combinations of alleles from each parent, allowing for a visual representation of inheritance patterns. By filling in the squares with the alleles from each parent, one can easily determine the expected ratios of different genotypes and phenotypes in the offspring.
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Genotype and Phenotype
Genotype refers to the genetic makeup of an organism, specifically the alleles it possesses for a particular gene. Phenotype, on the other hand, is the observable physical or biochemical characteristics of an organism, which result from the interaction of its genotype with the environment. Understanding the distinction between these two concepts is crucial for predicting how traits will be expressed in the offspring.
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Gamete Genotypes
Mendelian Inheritance
Mendelian inheritance is the set of principles that describe how traits are passed from parents to offspring through alleles. It includes concepts such as dominance, segregation, and independent assortment. These principles help in predicting the ratios of different phenotypes in offspring, especially when dealing with multiple traits, as seen in the cross provided in the question.
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