Textbook Question
What genetic defects result in the disorder xeroderma pigmentosum (XP) in humans? How do these defects create the phenotypes associated with the disorder?
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17. Mutation, Repair, and Recombination
Spontaneous Mutations
Multiple Choice
Which of the following tests determined that most mutations are spontaneous?
A
Luria and Delbrünk fluctuation test
B
Ames test
C
Two-hybrid test
D
Tautomer test
Verified step by step guidance1
Understand the context of the problem: The question is asking about a test that demonstrated the spontaneous nature of most mutations.
Identify the key tests mentioned: Luria and Delbrück fluctuation test, Ames test, Two-hybrid test, and Tautomer test.
Recall the purpose of each test: The Luria and Delbrück fluctuation test is known for demonstrating that mutations occur spontaneously rather than as a response to selective pressure.
Consider the Ames test: It is used to assess the mutagenic potential of chemical compounds, not specifically to determine the spontaneity of mutations.
Evaluate the Two-hybrid and Tautomer tests: The Two-hybrid test is used for studying protein-protein interactions, and the Tautomer test is not a standard test for mutation spontaneity. Therefore, the Luria and Delbrück fluctuation test is the correct answer.
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