Textbook Question
What are DNA microarrays? How are they used?
1009
views
Ch. 18 - Genomics, Bioinformatics, and Proteomics
Klug10th EditionEssentials of GeneticsISBN: 9780135588789
Not the one you use?Change textbookSelect a different textbook
Table of contents
- Ch. 1 - Introduction to Genetics16
- Ch. 2 - Mitosis and Meiosis28
- Ch. 3 - Mendelian Genetics37
- Ch. 4 - Modification of Mendelian Ratios53
- Ch. 5 - Sex Determination and Sex Chromosomes32
- Ch. 6 - Chromosome Mutations: Variation in Number and Arrangement37
- Ch. 7 - Linkage and Chromosome Mapping in Eukaryotes36
- Ch. 8 - Genetic Analysis and Mapping in Bacteria and Bacteriophages24
- Ch. 9 - DNA Structure and Analysis38
- Ch. 10 - DNA Replication29
- Ch. 11 - Chromosome Structure and DNA Sequence Organization22
- Ch. 12 - The Genetic Code and Transcription36
- Ch. 13 - Translation and Proteins27
- Ch. 14 - Gene Mutation, DNA Repair, and Transposition34
- Ch. 15 - Regulation of Gene Expression in Bacteria22
- Ch. 16 - Regulation of Gene Expression in Eukaryotes37
- Ch. 17 - Recombinant DNA Technology27
- Ch. 18 - Genomics, Bioinformatics, and Proteomics30
- Ch. 19 - The Genetics of Cancer21
- Ch. 20 - Quantitative Genetics and Multifactorial Traits37
- Ch. 21 - Population and Evolutionary Genetics45
Chapter 18, Problem 20b
An interactive Web site for the Human Proteome Map (HPM) is available at http://www.humanproteomemap.org. Visit this site, and then answer the question.
How many fetal tissues were analyzed?
Verified step by step guidance1
Since the question asks about the number of fetal tissues analyzed in the Human Proteome Map (HPM), the first step is to understand what the Human Proteome Map is: it is a resource that catalogs protein expression across various human tissues, including fetal and adult tissues.
Next, visit the website http://www.humanproteomemap.org as instructed, and navigate to the section or dataset that lists the tissues analyzed. This might be under categories like 'Tissue Atlas' or 'Data Overview'.
Look specifically for the fetal tissue category or filter the data to show only fetal tissues. The website should provide a list or a count of fetal tissues included in the analysis.
Count the number of distinct fetal tissues listed or reported in the dataset. This number represents how many fetal tissues were analyzed in the Human Proteome Map.
If the website provides downloadable data or supplementary information, you can verify the count by reviewing the metadata or documentation files that accompany the proteome data.
Verified video answer for a similar problem:
This video solution was recommended by our tutors as helpful for the problem above.
Video duration:
1mWas this helpful?
Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Human Proteome Map (HPM)
The Human Proteome Map is an online resource that catalogs protein expression across various human tissues and organs. It provides data on protein presence and abundance, helping researchers understand tissue-specific protein profiles, including fetal and adult tissues.
Recommended video:
Guided course
06:36
Proteomics
Fetal Tissue Analysis in Proteomics
Fetal tissue analysis involves studying protein expression in tissues from developing embryos or fetuses. This helps identify developmental stage-specific proteins and understand growth processes, which differ from adult tissue protein profiles.
Recommended video:
Guided course
06:36Proteomics
Navigating and Interpreting Online Biological Databases
Effectively using biological databases like the HPM requires skills in navigating web interfaces, locating relevant datasets, and interpreting summary statistics or metadata, such as the number of tissues analyzed, to answer specific research questions.
Recommended video:
Guided course
08:28Bioinformatics
Related Practice
Textbook Question
Annotation of the human genome sequence reveals a discrepancy between the number of protein-coding genes and the number of predicted proteins actually expressed by the genome. Proteomic analysis indicates that human cells are capable of synthesizing more than 100,000 different proteins and perhaps three times this number. What is the discrepancy, and how can it be reconciled?
731
views
Textbook Question
An interactive Web site for the Human Proteome Map (HPM) is available at http://www.humanproteomemap.org. Visit this site, and then answer the question.
How many proteins were identified in this project?
434
views
Textbook Question
An interactive Web site for the Human Proteome Map (HPM) is available at http://www.humanproteomemap.org. Visit this site, and then answer the question.
Use the 'Query' tab and select the 'Gene family' dropdown menu to do a search on the distribution of proteins encoded by a pathway of interest to you. Search in fetal tissues, adult tissues, or both.
536
views
Textbook Question
Researchers have compared candidate loci in humans and rats in search of loci in the human genome that are likely to contribute to the constellation of factors leading to hypertension [Stoll, M., et al. (2000). Genome Res. 10:473–482]. Through this research, they identified 26 chromosomal regions that they consider likely to contain hypertension genes. How can comparative genomics aid in the identification of genes responsible for such a complex human disease? The researchers state that comparisons of rat and human candidate loci to those in the mouse may help validate their studies. Why might this be so?
601
views
Textbook Question
Whole-exome sequencing (WES) is helping physicians diagnose a genetic condition that has defied diagnosis by traditional means. The implication here is that exons in the nuclear genome are sequenced in the hopes that, by comparison with the genomes of nonaffected individuals, a diagnosis might be revealed.
What are the strengths and weaknesses of this approach?
519
views