Question 1

Which of the following best describes the products formed when ethanamide (acetamide) undergoes acid hydrolysis with hydrochloric acid and heat?

Accepted Answer

A carboxylic acid and an ammonium salt

Question 2

What is the balanced chemical equation for the acid hydrolysis of ethanamide (acetamide) with HCl?

Accepted Answer

$$\mathrm{CH_3CONH_2 + H_2O + HCl \xrightarrow{heat} CH_3COOH + NH_3$ \cdot HCl}$$

Question 3

During base hydrolysis of N-methylpentanamide with NaOH and heat, which of the following are the correct IUPAC names for the products?

Accepted Answer

Sodium pentanoate and methylamine

Question 4

Which bond is broken during the hydrolysis of an amide (either acid or base hydrolysis)?

Accepted Answer

The bond between the carbonyl carbon and the nitrogen atom

Question 5

A student hydrolyzes N-methylpropanamide with NaOH and heat. Which of the following is the correct set of products?

Accepted Answer

Sodium propanoate and methylamine

Question 6

Which of the following statements about amines is TRUE?

Accepted Answer

Amines act as weak bases in water

Question 7

What is the main difference in the products of acid hydrolysis versus base hydrolysis of an amide?

Accepted Answer

Acid hydrolysis produces a carboxylic acid and an ammonium salt; base hydrolysis produces a carboxylate salt and an amine

Question 8

Given the reaction: $$\mathrm{CH_3CH_2CONHCH_3 + H_2O + HCl \xrightarrow{heat} ?}$$, what are the products?

Accepted Answer

$$\mathrm{CH_3CH_2COOH + CH_3NH_3^+Cl^-}$$

Question 9

Which of the following best explains why amines with up to 6 carbon atoms are generally soluble in water?

Accepted Answer

They can form hydrogen bonds with water molecules

Question 10

A patient is given a drug that is an amide. In the acidic environment of the stomach, what is the most likely chemical transformation that could occur?

Accepted Answer

The amide will undergo acid hydrolysis to form a carboxylic acid and an ammonium salt

Question 11

Which of the following is a correct description of the products of the base hydrolysis of N-methylpentanamide?

Accepted Answer

Sodium pentanoate and methylamine

Question 12

Which of the following equations correctly represents the base hydrolysis of N-methylpropanamide?

Accepted Answer

$$\mathrm{CH_3CH_2CONHCH_3 + NaOH \xrightarrow{heat} CH_3CH_2COO^-Na^+ + CH_3NH_2}$$

Question 13

Which of the following statements about the hydrolysis of amides is FALSE?

Accepted Answer

Acid hydrolysis of an amide produces a carboxylate salt and an amine

Question 14

Which of the following best describes the role of amines in biological systems?

Accepted Answer

Amines act as neurotransmitters

Question 15

A chemist wants to hydrolyze an amide to obtain a carboxylate salt and an amine. Which reagents and conditions should be used?

Accepted Answer

NaOH and heat

Question 16

Which of the following is a correct general equation for the acid hydrolysis of an amide?

Accepted Answer

$$\mathrm{RCONHR' + H_2O + HCl \xrightarrow{heat} RCOOH + R'NH_3$^+Cl^-}$$

Question 17

Which of the following is a correct general equation for the base hydrolysis of an amide?

Accepted Answer

$$\mathrm{RCONHR' + NaOH \xrightarrow{heat} RCOO^-Na^+ + R'NH_2$}$$

Question 18

Which of the following is a correct description of the products of the acid hydrolysis of N-methylpentanamide?

Accepted Answer

Pentanoic acid and methylammonium chloride

Question 19

Which of the following best explains why amides are generally stable compounds under physiological conditions?

Accepted Answer

Amides require heat and either acid or base to hydrolyze

Hydrolysis of Amides: Acid and Base Reactions in GOB Chemistry

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