Multiple Choice
Which of the following is NOT considered a reservoir for pathogens?
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1. Introduction to Microbiology
Introduction to Microbiology
Multiple Choice
Which one of the following steps does NOT occur during the multiplication of a picornavirus?
A
Synthesis of a DNA intermediate
B
Attachment of the virus to host cell receptors
C
Replication of viral RNA in the cytoplasm
D
Translation of viral RNA into a polyprotein
Verified step by step guidance1
Step 1: Understand the nature of picornaviruses. Picornaviruses are positive-sense single-stranded RNA viruses, meaning their genome can directly serve as mRNA for protein synthesis.
Step 2: Review the typical steps in picornavirus multiplication: attachment to host cell receptors, entry, uncoating, translation of viral RNA into a polyprotein, replication of viral RNA in the cytoplasm, assembly, and release.
Step 3: Recognize that because picornaviruses have RNA genomes, they do not require a DNA intermediate for replication. DNA intermediates are characteristic of retroviruses or DNA viruses, not RNA viruses like picornaviruses.
Step 4: Confirm that attachment to host cell receptors is an essential first step for viral entry, and translation of viral RNA into a polyprotein occurs immediately after uncoating in the cytoplasm.
Step 5: Conclude that the step 'Synthesis of a DNA intermediate' does NOT occur during picornavirus multiplication, as their replication cycle involves RNA replication directly in the cytoplasm without a DNA stage.
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