Textbook Question
Why is a person who produces a large amount of IgE more likely to experience anaphylactic shock than a person who instead produces a large amount of IgG?
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Ch. 18 - Immune Disorders
Bauman6th EditionMicrobiology with Diseases by TaxonomyISBN: 9780134832302
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Table of contents
- Ch. 1 - A Brief History of Microbiology31
- Ch. 2 - The Chemistry of Microbiology28
- Ch. 3 - Cell Structure and Function39
- Ch. 4 - Microscopy, Staining, and Classification25
- Ch. 5 - Microbial Metabolism51
- Ch. 6 - Microbial Nutrition and Growth37
- Ch. 7 - Microbial Genetics51
- Ch. 8 - Recombinant DNA Technology21
- Ch. 9 - Controlling Microbial Growth in the Environment36
- Ch. 10 - Controlling Microbial Growth in the Body: Antimicrobial Drugs21
- Ch. 11 - Characterizing and Classifying Prokaryotes29
- Ch. 12 - Characterizing and Classifying Eukaryotes34
- Ch. 13 - Characterizing and Classifying Viruses, Viroids, and Prions23
- Ch. 14 - Infection, Infectious Diseases, and Epidemiology35
- Ch. 15 - Innate Immunity34
- Ch. 16 - Adaptive Immunity21
- Ch. 17 - Immunization and Immune Testing29
- Ch. 18 - Immune Disorders22
- Ch. 19 - Pathogenic Gram-Positive Bacteria25
- Ch. 20 - Pathogenic Gram-Negative Cocci and Bacilli28
- Ch. 21 - Rickettsias, Chlamydias, Spirochetes, and Vibrios25
- Ch. 22 - Pathogenic Fungi47
- Ch. 23 - Parasitic Protozoa, Helminths, and Arthropod Vectors44
- Ch. 24 - Pathogenic DNA Viruses23
- Ch. 25 - Pathogenic RNA Viruses30
- Ch. 26 - Applied and Industrial Microbiology29
- Ch. 27 - Microbial Ecology and Microbiomes22
Bauman6th EditionMicrobiology with Diseases by TaxonomyISBN: 9780134832302Not the one you use?Change textbook
Chapter 18, Problem 2
The major inflammatory mediator released by degranulating mast cells in type I hypersensitivity is:
a. Immunoglobulin
b. Complement
c. Histamine
d. Interleukin
e. Prostaglandin
Verified step by step guidance1
Understand the context: Type I hypersensitivity is an immediate allergic reaction involving mast cells and basophils.
Recall that mast cells, when activated during type I hypersensitivity, release various inflammatory mediators stored in their granules.
Identify the major mediator released upon mast cell degranulation, which causes symptoms like vasodilation, increased vascular permeability, and smooth muscle contraction.
Compare the options: immunoglobulin (antibody), complement (plasma proteins), histamine (a biogenic amine), interleukin (cytokine), and prostaglandin (lipid mediator).
Recognize that histamine is the primary and most immediate mediator released from mast cell granules during type I hypersensitivity.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Type I Hypersensitivity
Type I hypersensitivity is an immediate allergic reaction mediated by IgE antibodies. Upon exposure to an allergen, IgE binds to mast cells, triggering their degranulation and release of inflammatory mediators, leading to symptoms like swelling, redness, and itching.
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Types of Phosphorylation
Mast Cell Degranulation
Mast cells are immune cells that store inflammatory mediators in granules. When activated by allergens via IgE, they release these mediators rapidly, a process called degranulation, which initiates and amplifies allergic inflammation.
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Histamine as an Inflammatory Mediator
Histamine is a key chemical released from mast cell granules during allergic reactions. It increases blood vessel permeability and causes smooth muscle contraction, leading to classic allergy symptoms such as swelling, redness, and bronchoconstriction.
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02:152) Release of Inflammatory Mediators & Other Cytokines
Related Practice
Textbook Question
Indicate whether each statement is true or false. If the statement is false, change the underlined word or phrase to make the statement true.
________ Cyclosporine is released by degranulating mast cells.
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Textbook Question
Indicate whether each statement is true or false. If the statement is false, change the underlined word or phrase to make the statement true.
_____ Type III hypersensitivity reactions may lead to the development of glomerulonephritis.
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Textbook Question
Why is a child born to an Rh+ mother not susceptible to Rh-related hemolytic disease of the newborn?
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Textbook Question
The immunoglobulin class that mediates type I hypersensitivity is:
a. IgA
b. IgM
c. IgG
d. IgD
e. IgE
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Textbook Question
Label the four types of grafts on the accompanying figure.
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