Textbook Question
Fill in the table.
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Ch. 13 - Immune System Disorders
Norman-McKay2nd EditionMicrobiology: Basic and Clinical PrinciplesISBN: 9780137661619
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Table of contents
- Ch. 1 - Introduction to Microbiology22
- Ch. 2 - Biochemistry Basics19
- Ch. 3 - Introduction to Prokaryotic Cells17
- Ch. 4 - Introduction to Eukaryotic Cells16
- Ch. 5 - Genetics25
- Ch. 6 - Viruses and Prions12
- Ch. 7 - Fundamentals of Microbial Growth20
- Ch. 8 - Microbial Metabolism16
- Ch. 9 - Principles of Infectious Disease and Epidemiology11
- Ch. 10 - Host Microbe Interactions and Pathogenesis19
- Ch. 11 - Innate Immunity24
- Ch. 12 - Adaptive Immunity22
- Ch. 13 - Immune System Disorders15
- Ch. 14 - Biomedical Applications: Vaccines, Diagnostics, Therapeutics, and Molecular Method14
- Ch. 15 - Antimicrobial Drugs18
- Ch. 16 - Respiratory System Infections16
- Ch. 17 - Skin and Eye Infections19
- Ch. 18 - Nervous System Infections12
- Ch. 19 - Digestive System Infections20
- Ch. 20 - Urinary and Reproductive System Infections10
- Ch. 21 - Cardiovascular and Lymphatic Infections15
Norman-McKay2nd EditionMicrobiology: Basic and Clinical PrinciplesISBN: 9780137661619Not the one you use?Change textbook
Chapter 13, Problem 4
Which of the following would be recommended as a means to diagnose a type I sensitivity? Select all that apply.
a. Skin prick test
b. IgG titers
c. IgM titers
d. IgE titers
e. Histamine levels
Verified step by step guidance1
Step 1: Understand that Type I hypersensitivity reactions are immediate allergic reactions mediated primarily by Immunoglobulin E (IgE) antibodies.
Step 2: Recognize that diagnostic methods for Type I hypersensitivity focus on detecting IgE antibodies or the physiological response they trigger.
Step 3: Identify that a skin prick test is commonly used to diagnose Type I hypersensitivity by introducing small amounts of allergens into the skin and observing an immediate reaction.
Step 4: Note that measuring IgE titers in the blood can help confirm sensitization to specific allergens, as elevated IgE levels are characteristic of Type I hypersensitivity.
Step 5: Understand that IgG and IgM titers are not typically used for diagnosing Type I hypersensitivity, and histamine levels may rise during reactions but are not standard diagnostic tests.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Type I Hypersensitivity
Type I hypersensitivity is an immediate allergic reaction mediated by IgE antibodies. Upon exposure to an allergen, IgE binds to mast cells and basophils, triggering the release of histamine and other mediators, causing symptoms like itching, swelling, and anaphylaxis.
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Diagnostic Tests for Type I Hypersensitivity
Diagnostic methods for type I hypersensitivity include skin prick tests, which introduce allergens to the skin to observe immediate reactions, and measuring serum IgE titers, which indicate sensitization to specific allergens. These tests help confirm allergic responses.
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Role of Immunoglobulins in Allergy Testing
Different immunoglobulins serve distinct roles: IgE is central to allergic reactions, while IgG and IgM are involved in other immune responses. Measuring IgE levels is relevant for allergy diagnosis, whereas IgG and IgM titers are not typically used for type I hypersensitivity.
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Related Practice
Textbook Question
Which of the following is the most suggestive of an anaphylactic reaction? (NCLEX/HESI/TEAS)
a. Sudden fever
b. A localized rash
c. Nasal congestion
d. Hemorrhage
e. Respiratory distress
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Textbook Question
A patient has developed a type III reaction to a drug. Which of the following is the most immediate action required?
a. Lower the patient’s fever
b. Stop administration of the drug
c. Treat the patient’s skin rash to avoid possible infections
d. Hook the patient up to an IV for rehydration therapy
e. Administer antihistamines to limit the response
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Textbook Question
Which type of hypersensitivity is not antibody mediated?
a. Type I hypersensitivities
b. Type II hypersensitivities
c. Type III hypersensitivities
d. Type IV hypersensitivities
e. Antibodies mediate all of these.
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Textbook Question
Indicate the true statements, and then reword the false statements so they are true.
a. Immunodeficiencies are associated with a decreased cancer risk
b. Type I reactions are mediated by IgG antibodies
c. Autoimmune disorders are not caused by type I hypersensitivities
d. Systemic lupus is mainly mediated by a type III hypersensitivity
e. A person with type 0- blood is called a universal donor
f. Immunotherapies are useful to reduce type II reactions
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Textbook Question
Which scenario presents the greatest risk for HDN developing?
a. O− mother with O+ fetus
b. A+ mother with O+ fetus
c. B−mother with AB− fetus
d. A−mother with O−fetus
e. AB+ mother with AB−fetus
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