Which of the following statements about taking acetaminophen (paracetamol) after heavy alcohol use is most correct?

Combining acetaminophen with recent heavy alcohol use increases the risk of liver injury because both are processed by the liver and can produce toxic metabolites when hepatic pathways are overwhelmed.

Taking acetaminophen while drinking prevents a hangover by accelerating alcohol elimination through induction of specific ethanol-metabolizing enzymes.

Acetaminophen is completely safe to take immediately after drinking because alcohol neutralizes its hepatotoxic metabolites and reduces the drug’s liver burden.

The hepatic risk is negligible provided the acetaminophen dose is doubled to counterbalance alcohol’s sedative effects, because a higher dose enhances analgesia without increasing liver toxicity.