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Multiple Choice
Which of the following groups in electrophilic aromatic substitution () reactions exhibit synergistic activation when present on a benzene ring?
A
Carboxyl and Nitro
B
Chloro and Methyl
C
Hydroxyl and Amino
D
Methoxy and Nitro
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1
Understand the concept of electrophilic aromatic substitution (EAS): EAS is a reaction where an electrophile replaces a hydrogen atom on an aromatic ring, such as benzene. The presence of substituents on the benzene ring can influence the reactivity and orientation of the substitution.
Identify the role of substituents: Substituents on a benzene ring can be either activating or deactivating. Activating groups donate electron density to the ring, making it more reactive towards electrophiles, while deactivating groups withdraw electron density, making the ring less reactive.
Recognize synergistic activation: Synergistic activation occurs when two substituents on a benzene ring work together to enhance the reactivity of the ring towards electrophiles more than either would alone.
Analyze the given groups: Hydroxyl (-OH) and amino (-NH2) groups are both strong electron-donating groups through resonance and inductive effects. They increase the electron density on the benzene ring, making it more reactive towards electrophiles.
Conclude the synergistic effect: When both hydroxyl and amino groups are present on a benzene ring, they can work together to significantly increase the reactivity of the ring in EAS reactions, demonstrating synergistic activation.