Question 1

Which of the following is the correct order of reactivity for carboxylic acid derivatives towards nucleophilic acyl substitution?

Accepted Answer

$$RCOCl \u003e (RCO)_2O \u003e RCOOR' \u003e $$RCONH_2$$

Question 2

What is the product of the hydrolysis of acetic anhydride ($$ (CH_3CO)_2O ) $$with water?

Accepted Answer

$$2CH_3COOH$$

Question 3

Which of the following best describes the leaving group ability in nucleophilic acyl substitution reactions?

Accepted Answer

The least basic leaving group is the best.

Question 4

What is the correct IUPAC name for the following compound: $$CH_3CONHCH_3$$?

Accepted Answer

N-methylacetamide

Question 5

Which of the following reactions is used in the ancient process of soap making (saponification)?

Accepted Answer

Hydrolysis of a triglyceride with KOH

Question 6

What is the product of the hydrolysis of benzoyl chloride ($$C_6H_5COCl) $$with water?

Accepted Answer

$$C_6H_5COOH + HCl$$

Question 7

Which of the following statements about amides is TRUE?

Accepted Answer

Amides have significant double bond character due to resonance.

Question 8

What is the correct name for the cyclic compound shown: $$\displaystyle \begin{array}{c} 	ext{O} \ | \ 	ext{C} \ / \ 	ext{C} \ | \ 	ext{NH} \ \end{array} ($$five-membered ring with two carbonyls and one NH)?

Accepted Answer

Succinimide

Question 9

Which of the following is the correct product of the reaction: $$CH_3COCl + CH_3OH \rightarrow$$ ?

Accepted Answer

$$CH_3COOCH_3 + HCl$$

Question 10

Which principle explains why increasing the concentration of water drives the hydrolysis of an ester to completion?

Accepted Answer

Le Chatelier's Principle

Question 11

Which of the following is the correct name for $$CH_3CN$$?

Accepted Answer

Ethanenitrile

Question 12

Which of the following is NOT a carboxylic acid derivative?

Accepted Answer

Ketone

Question 13

What is the product of the reaction: $$RCOOR' + H_2O \xrightarrow{H^+} RCOOH + R'OH$$?

Accepted Answer

Acid-catalyzed ester hydrolysis

Question 14

Which of the following is TRUE about the mechanism of acid chloride hydrolysis?

Accepted Answer

It involves nucleophilic attack by water followed by elimination of chloride ion.

Question 15

Which of the following is the correct name for $$C_6H_5CN$$?

Accepted Answer

Benzonitrile

Question 16

Which of the following statements about ester hydrolysis is correct?

Accepted Answer

Acidic hydrolysis is reversible, while basic hydrolysis is irreversible.

Question 17

What is the product of saponification of a triglyceride with KOH?

Accepted Answer

Glycerol and potassium carboxylate salts (soap)

Question 18

Which of the following is the correct structure for an acid anhydride?

Accepted Answer

$$RCOOCOR'$$

Question 19

Which of the following is the correct name for $$CH_3COOCH_2CH_3$$?

Accepted Answer

Ethyl ethanoate

Carboxylic Acid Derivatives: Structures, Nomenclature, Properties, and Reactions

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