Which statement best describes the primary mechanism of action of the lipase inhibitor orlistat (Alli)?

Acts centrally to dampen hunger signals in the hypothalamus by modulating neuropeptide Y, thereby reducing caloric intake over time through central appetite suppression mechanisms not directly related to intestinal fat hydrolysis.

Inhibits adipose tissue lipoprotein lipase, preventing peripheral uptake of circulating triglyceride-rich lipoproteins into adipocytes and thereby causing systemic reductions in fat storage rather than directly altering intestinal digestion.

Inhibits pancreatic lipase, reducing triglyceride breakdown in the intestine and decreasing fat absorption.

Stimulates bile acid secretion from the gallbladder to emulsify and increase fecal loss of lipids, which indirectly reduces fat absorption but does not act on lipase enzymes themselves.