Which statement best analyzes why grapefruit juice increases plasma levels of some medications?

Grapefruit juice universally induces all hepatic enzymes causing drugs to be metabolized faster and thus decreases systemic concentrations for all oral medications.

Grapefruit juice directly binds circulating drugs in plasma, forming insoluble complexes that are rapidly excreted, thereby preventing toxicity.

Compounds in grapefruit inhibit intestinal CYP3A4 and certain transporters, reducing first-pass metabolism and increasing systemic drug availability.

Grapefruit acts as an antagonist at drug receptors in peripheral tissues, blocking drug action without changing systemic concentrations.