Step 2: Analyze statement I. First-generation antidepressants (e.g., MAOIs) do not primarily target serotonin reuptake; instead, they inhibit the enzyme monoamine oxidase, which breaks down serotonin, norepinephrine, and dopamine. Second-generation antidepressants, such as SSRIs, do target serotonin reuptake. Therefore, statement I is partially incorrect.