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Multiple Choice
Which of the following drug classes specifically inhibits neuronal transmission in helminths?
A
Avermectins
B
Benzimidazoles
C
Tetracyclines
D
Fluoroquinolones
Verified step by step guidance
1
Begin by understanding the mechanism of action for each drug class listed. This will help identify which one specifically targets neuronal transmission in helminths.
Avermectins are known to enhance the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in helminths, leading to paralysis and death of the parasite. This indicates their role in inhibiting neuronal transmission.
Benzimidazoles work by disrupting microtubule formation in helminths, which affects cell division and energy metabolism, but not directly neuronal transmission.
Tetracyclines are antibiotics that inhibit protein synthesis by binding to the 30S ribosomal subunit, primarily affecting bacteria rather than helminths.
Fluoroquinolones inhibit bacterial DNA gyrase and topoisomerase IV, affecting DNA replication in bacteria, not neuronal transmission in helminths.