Table of contents

1. Introduction to Anatomy & Physiology5h 43m
2. Cell Chemistry & Cell Components12h 36m
3. Energy & Cell Processes10h 6m
4. Tissues & Histology10h 3m
5. Integumentary System2h 20m
6. Bones & Skeletal Tissue2h 16m
7. The Skeletal System2h 35m
8. Joints2h 17m
9. Muscle Tissue2h 33m
10. Muscles1h 11m
11. Nervous Tissue and Nervous System1h 35m
12. The Central Nervous System1h 6m
- Introduction to the Central Nervous System
  18m
- The Cerebrum
  48m
13. The Peripheral Nervous System1h 26m
14. The Autonomic Nervous System1h 38m
15. The Special Senses2h 41m
16. The Endocrine System2h 48m
17. The Blood3h 22m
18. The Heart3h 42m
19. The Blood Vessels3h 35m
20. The Lymphatic System3h 16m
21. The Immune System14h 37m
22. The Respiratory System3h 20m
23. The Digestive System2h 5m
24. Metabolism and Nutrition4h 0m
25. The Urinary System2h 39m
26. Fluid and Electrolyte Balance, Acid Base Balance37m
27. The Reproductive System2h 5m
28. Human Development1h 21m
29. Heredity3h 32m

21. The Immune System

Major Histocompatibility Complex Molecules

Anatomy & Physiology

21. The Immune System

Major Histocompatibility Complex Molecules

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Multiple Choice

Which MHC class molecule is most critical to match for transplant success?

MHC Class II

MHC Class I

MHC Class IV

MHC Class III

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Verified step by step guidance

Understand the role of MHC (Major Histocompatibility Complex) molecules in the immune system. MHC molecules are proteins found on the surface of cells that help the immune system recognize self from non-self. They are critical in organ transplantation because mismatched MHC molecules can lead to immune rejection.

Learn the difference between MHC Class I and MHC Class II molecules. MHC Class I molecules are present on all nucleated cells and are involved in presenting antigens to cytotoxic T cells (CD8+). MHC Class II molecules are found on antigen-presenting cells (like macrophages, dendritic cells, and B cells) and present antigens to helper T cells (CD4+).

Recognize that MHC Class II molecules are particularly important in transplant success because they play a key role in activating the immune response. Matching MHC Class II molecules between donor and recipient reduces the likelihood of immune rejection.

Eliminate incorrect options: MHC Class III molecules are involved in the complement system and do not directly influence transplant compatibility. MHC Class IV is not a recognized category in the MHC classification system.

Conclude that MHC Class II molecules are the most critical to match for transplant success, as they are central to the immune system's ability to recognize and respond to foreign tissue.