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Multiple Choice
What best describes the binding of the CD4 and CD8 co-receptors to MHC molecules?
A
Both CD4 and CD8 bind to MHC class II molecules.
B
CD4 binds to MHC class II molecules, while CD8 binds to MHC class I molecules.
C
CD4 binds to MHC class I molecules, while CD8 binds to MHC class II molecules.
D
Both CD4 and CD8 bind to MHC class I molecules.
Verified step by step guidance
1
Understand the role of CD4 and CD8 co-receptors in the immune system. CD4 and CD8 are glycoproteins found on the surface of T cells, which are crucial for the immune response.
Recognize the difference between MHC class I and MHC class II molecules. MHC class I molecules are present on almost all nucleated cells and present endogenous antigens, while MHC class II molecules are found on antigen-presenting cells and present exogenous antigens.
Identify the specific binding interactions: CD4 co-receptors are primarily found on helper T cells and bind to MHC class II molecules, facilitating the activation of these T cells by antigen-presenting cells.
Understand that CD8 co-receptors are found on cytotoxic T cells and bind to MHC class I molecules, which is essential for the recognition and destruction of infected or cancerous cells.
Conclude that the correct description of the binding is: CD4 binds to MHC class II molecules, while CD8 binds to MHC class I molecules, reflecting their roles in the immune response.