Multiple Choice
Which of the following are true of Class I Major Histocompatibility Complex (MHC) molecules?
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21. The Immune System
Major Histocompatibility Complex Molecules
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Which of the following statements regarding MHC I proteins is true?
A
MHC I proteins are involved in the presentation of extracellular antigens.
B
MHC I proteins are only found on antigen-presenting cells.
C
MHC I proteins present antigens to CD4+ T helper cells.
D
MHC I proteins are expressed on all nucleated cells.
Verified step by step guidance1
Understand the role of MHC I proteins: MHC I proteins are crucial for the immune system, primarily involved in presenting antigens to T cells.
Identify the type of antigens presented by MHC I: MHC I proteins present endogenous antigens, which are typically derived from proteins synthesized within the cell, such as viral proteins in infected cells.
Determine the cell types expressing MHC I: MHC I proteins are expressed on all nucleated cells, not just antigen-presenting cells. This is a key feature that distinguishes them from MHC II proteins.
Clarify the interaction with T cells: MHC I proteins present antigens to CD8+ cytotoxic T cells, not CD4+ T helper cells, which interact with MHC II proteins.
Review the correct statement: Based on the above clarifications, the true statement is that MHC I proteins are expressed on all nucleated cells.
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