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Multiple Choice
Which pathophysiologic phenomenon may result in a diagnosis of Cushing disease?
A
Overproduction of parathyroid hormone
B
Excessive secretion of adrenocorticotropic hormone (ACTH) by the pituitary gland
C
Decreased secretion of thyroid hormones
D
Insufficient production of insulin by the pancreas
Verified step by step guidance
1
Understand the context of Cushing disease: It is a condition caused by excessive cortisol levels in the body, often due to overproduction of adrenocorticotropic hormone (ACTH) by the pituitary gland.
Review the role of ACTH: ACTH is a hormone secreted by the anterior pituitary gland that stimulates the adrenal glands to produce cortisol. Excessive secretion of ACTH leads to overstimulation of the adrenal glands and elevated cortisol levels.
Eliminate incorrect options: Overproduction of parathyroid hormone is associated with calcium imbalance, not cortisol. Decreased secretion of thyroid hormones leads to hypothyroidism, and insufficient production of insulin by the pancreas results in diabetes mellitus. These are unrelated to Cushing disease.
Focus on the correct pathophysiologic mechanism: Excessive secretion of ACTH by the pituitary gland is the primary cause of Cushing disease, as it directly leads to increased cortisol production.
Summarize the diagnosis: The pathophysiologic phenomenon resulting in Cushing disease is the excessive secretion of ACTH by the pituitary gland, which causes hypercortisolism.