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Multiple Choice
Which of the following are the main mediators/initiators of Type II hypersensitivity reactions?
A
Histamine
B
IgE antibodies
C
IgG and IgM antibodies
D
T lymphocytes
Verified step by step guidance
1
Understand that Type II hypersensitivity reactions are also known as cytotoxic hypersensitivity reactions. These reactions involve the destruction of target cells by the immune system.
Recognize that the main feature of Type II hypersensitivity is the involvement of antibodies that bind to antigens on the surface of target cells, leading to cell destruction.
Identify the types of antibodies involved in Type II hypersensitivity. These are typically IgG and IgM antibodies, which are responsible for binding to the antigens on the cell surfaces.
Differentiate between the roles of various antibodies: IgE is primarily involved in Type I hypersensitivity (allergic reactions), while IgG and IgM are involved in Type II hypersensitivity.
Conclude that the main mediators/initiators of Type II hypersensitivity reactions are IgG and IgM antibodies, as they are responsible for targeting and destroying cells with specific antigens.