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Multiple Choice
Which ions are necessary for both the intrinsic and extrinsic pathways of the coagulation cascade?
A
Magnesium ions
B
Potassium ions
C
Sodium ions
D
Calcium ions
Verified step by step guidance
1
Understand the coagulation cascade: The coagulation cascade is a series of events that lead to the formation of a blood clot. It consists of two pathways: intrinsic and extrinsic, which converge into a common pathway.
Identify the role of ions in the coagulation cascade: Ions play a crucial role in various physiological processes, including the coagulation cascade. They act as cofactors that are necessary for the activation of certain enzymes involved in the cascade.
Focus on calcium ions: Calcium ions (
) are essential for both the intrinsic and extrinsic pathways. They are required for the activation of several clotting factors, including factor IV, which is calcium itself.
Explore the intrinsic pathway: In the intrinsic pathway, calcium ions are necessary for the activation of factors IX and X, which are crucial for the progression of the cascade.
Explore the extrinsic pathway: In the extrinsic pathway, calcium ions are required for the activation of factor VII, which then activates factor X, leading to the common pathway and ultimately clot formation.