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Multiple Choice
What did Sutherland discover about glycogen metabolism in liver cells?
A
The role of cyclic AMP as a second messenger in glycogen breakdown
B
The involvement of insulin in promoting glycogen synthesis
C
The direct conversion of glycogen to glucose without intermediates
D
The storage of glycogen in muscle cells rather than liver cells
Verified step by step guidance
1
Begin by understanding the context of glycogen metabolism in liver cells. Glycogen is a stored form of glucose, and its metabolism involves both synthesis and breakdown processes.
Consider the role of hormones in glycogen metabolism. Insulin and glucagon are key hormones that regulate glycogen synthesis and breakdown, respectively.
Explore the concept of second messengers in cellular signaling. Cyclic AMP (cAMP) is a well-known second messenger that plays a crucial role in transmitting signals from hormones like glucagon to initiate glycogen breakdown.
Examine the process of glycogen breakdown. When glucagon binds to its receptor on liver cells, it activates adenylate cyclase, which converts ATP to cyclic AMP. This increase in cAMP levels leads to the activation of protein kinase A (PKA), which then phosphorylates enzymes involved in glycogen breakdown.
Reflect on the discovery by Sutherland, which highlighted the importance of cyclic AMP as a second messenger in the process of glycogen breakdown in liver cells, rather than direct conversion of glycogen to glucose or storage in muscle cells.