Multiple Choice
What is the primary difference between the rough endoplasmic reticulum (ER) and the smooth endoplasmic reticulum (ER) in eukaryotic cells?
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2. Cell Chemistry & Cell Components
Endomembrane System: Protein Secretion
Multiple Choice
Which of the following correctly describes the steps required for protein transport into the rough endoplasmic reticulum (ER)?
A
Proteins are synthesized in the nucleus and then transported to the rough ER.
B
Proteins are synthesized in the Golgi apparatus and then transported to the rough ER.
C
Proteins are synthesized in the smooth ER and then transported to the rough ER.
D
Proteins are synthesized in the cytoplasm and then transported into the rough ER via signal recognition particles.
Verified step by step guidance1
Understand that protein synthesis begins in the cytoplasm where ribosomes are located.
Recognize that proteins destined for the rough ER have a specific signal sequence that directs them to the ER.
Learn that the signal recognition particle (SRP) binds to the signal sequence of the nascent protein, temporarily halting translation.
The SRP-protein complex then binds to the SRP receptor on the rough ER membrane, guiding the ribosome to the ER.
Once the ribosome is docked on the ER, translation resumes, and the growing polypeptide chain is threaded into the ER lumen through a translocon channel.
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