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Multiple Choice
During the action potential, when does sodium permeability initially decrease?
A
During the resting membrane potential
B
During the absolute refractory period
C
At the peak of the action potential
D
At the onset of depolarization
Verified step by step guidance
1
Understand the concept of an action potential: An action potential is a rapid electrical signal that travels along the membrane of a neuron or muscle cell. It involves changes in the permeability of the membrane to sodium (Na⁺) and potassium (K⁺) ions.
Review the phases of an action potential: The key phases are resting membrane potential, depolarization, peak of the action potential, repolarization, and hyperpolarization. Each phase is associated with specific changes in ion permeability.
Focus on sodium permeability: During depolarization, voltage-gated sodium channels open, causing a rapid influx of Na⁺ ions into the cell, which increases sodium permeability. This continues until the peak of the action potential.
Identify when sodium permeability decreases: At the peak of the action potential, voltage-gated sodium channels begin to inactivate, reducing sodium permeability. This marks the transition from depolarization to repolarization.
Relate this to the options provided: Sodium permeability does not decrease during the resting membrane potential or the onset of depolarization. It decreases specifically at the peak of the action potential, which is the correct answer.