Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

7. Enzyme Inhibition and Regulation

Enzyme Inhibition

Biochemistry

7. Enzyme Inhibition and Regulation

Enzyme Inhibition

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Multiple Choice

Which of the following molecules inhibits isocitrate dehydrogenase?

NAD+

ATP

Isocitrate

ADP

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Verified step by step guidance

Understand the role of isocitrate dehydrogenase in the citric acid cycle. It is an enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate, producing NADH and CO₂.

Recognize that isocitrate dehydrogenase is regulated by allosteric effectors. These effectors can either activate or inhibit the enzyme depending on the energy needs of the cell.

Recall that ATP (adenosine triphosphate) is a high-energy molecule that signals a sufficient energy state in the cell. When ATP levels are high, it acts as an allosteric inhibitor of isocitrate dehydrogenase to slow down the citric acid cycle and conserve resources.

Contrast ATP with ADP (adenosine diphosphate), which signals a low-energy state in the cell. ADP acts as an allosteric activator of isocitrate dehydrogenase, increasing the enzyme's activity to produce more energy.

Conclude that among the given options, ATP is the molecule that inhibits isocitrate dehydrogenase, as it reflects a high-energy state and reduces the enzyme's activity to prevent excessive energy production.