Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

7. Enzyme Inhibition and Regulation

Enzyme Inhibition

Biochemistry

7. Enzyme Inhibition and Regulation

Enzyme Inhibition

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Multiple Choice

If acetylcholinesterase became mutated and nonfunctional, which of the following would most likely occur?

Enhanced reuptake of acetylcholine into the presynaptic neuron

Increased breakdown of acetylcholine

Accumulation of acetylcholine in the synaptic cleft

Decreased stimulation of postsynaptic receptors

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Verified step by step guidance

Step 1: Understand the role of acetylcholinesterase. Acetylcholinesterase is an enzyme responsible for breaking down acetylcholine in the synaptic cleft into acetate and choline, which terminates the signal transmission between neurons.

Step 2: Analyze the impact of a nonfunctional acetylcholinesterase. If acetylcholinesterase is mutated and nonfunctional, it cannot break down acetylcholine effectively, leading to its accumulation in the synaptic cleft.

Step 3: Evaluate the options provided. Enhanced reuptake of acetylcholine into the presynaptic neuron would not occur because acetylcholine remains in the synaptic cleft. Increased breakdown of acetylcholine is incorrect because the enzyme responsible for this process is nonfunctional.

Step 4: Consider the physiological consequences. Accumulation of acetylcholine in the synaptic cleft would lead to prolonged stimulation of postsynaptic receptors, not decreased stimulation, as acetylcholine remains available to bind to these receptors.

Step 5: Conclude that the correct answer is 'Accumulation of acetylcholine in the synaptic cleft,' as this aligns with the expected outcome of a nonfunctional acetylcholinesterase enzyme.