Multiple Choice
How is chymotrypsinogen converted to chymotrypsin?
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7. Enzyme Inhibition and Regulation
Zymogens
Multiple Choice
Pepsinogen, a zymogen of the digestive enzyme pepsin, is secreted primarily by which cells in the stomach?
A
Parietal (oxyntic) cells of the gastric glands
B
Pancreatic acinar cells
C
Chief (zymogenic) cells of the gastric glands
D
G cells of the gastric antrum
Verified step by step guidance1
Understand that pepsinogen is an inactive precursor (zymogen) of the enzyme pepsin, which is involved in protein digestion in the stomach.
Recall the different cell types in the stomach and their primary secretions: Parietal cells secrete hydrochloric acid and intrinsic factor; G cells secrete gastrin; Chief cells secrete pepsinogen.
Identify that pancreatic acinar cells are located in the pancreas and secrete digestive enzymes, not pepsinogen.
Recognize that the chief (zymogenic) cells of the gastric glands are responsible for secreting pepsinogen, which is then activated to pepsin in the acidic environment of the stomach.
Conclude that the correct answer is the chief (zymogenic) cells of the gastric glands, as they specifically produce pepsinogen.
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