Multiple Choice
How is chymotrypsinogen converted to chymotrypsin?
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7. Enzyme Inhibition and Regulation
Zymogens
Multiple Choice
Which of the following digestive enzymes is NOT produced by the pancreas (i.e., is primarily produced in the gastric mucosa)?
A
Pepsin
B
Chymotrypsinogen
C
Trypsinogen
D
Procarboxypeptidase
Verified step by step guidance1
Understand the role of the pancreas in digestion: The pancreas produces several digestive enzymes that are secreted into the small intestine to aid in the breakdown of proteins, carbohydrates, and fats.
Identify the enzymes listed and their origins: Chymotrypsinogen, Trypsinogen, and Procarboxypeptidase are all inactive precursors (zymogens) of pancreatic enzymes involved in protein digestion.
Recall that Pepsin is a digestive enzyme primarily produced in the gastric mucosa (stomach lining), not the pancreas. It functions in the acidic environment of the stomach to begin protein digestion.
Compare the site of production for each enzyme: Since Pepsin is produced in the stomach and the others are produced by the pancreas, Pepsin is the enzyme that is NOT produced by the pancreas.
Conclude that the enzyme produced in the gastric mucosa and not by the pancreas is Pepsin, distinguishing it from the pancreatic zymogens listed.
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