Multiple Choice
In glycolysis, which molecule is the initial substrate that enters the pathway and is phosphorylated by hexokinase (or glucokinase in liver)?
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Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway
Glycolysis 1
Multiple Choice
In the glycolysis pathway, what is the net amount of ATP produced per molecule of glucose converted to two molecules of pyruvate?
A
36 ATP (net)
B
0 ATP (net)
C
2 ATP (net)
D
4 ATP (net)
Verified step by step guidance1
Understand that glycolysis is the metabolic pathway that converts one molecule of glucose into two molecules of pyruvate, producing energy in the form of ATP and NADH.
Identify the ATP-consuming steps: In the initial phase of glycolysis (investment phase), 2 ATP molecules are used to phosphorylate glucose and its intermediates.
Identify the ATP-producing steps: In the later phase (payoff phase), 4 ATP molecules are generated through substrate-level phosphorylation as the pathway converts intermediates into pyruvate.
Calculate the net ATP production by subtracting the ATP consumed from the ATP produced: Net ATP = ATP produced - ATP consumed.
Conclude that the net ATP yield per glucose molecule in glycolysis is 2 ATP, since 4 ATP are produced and 2 ATP are used.
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