Multiple Choice
Which amino acid is least likely to be found in one of the transmembrane domains of GPCR43?
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3. Amino Acids
Amino Acid Groups
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Which of the following amino acids is most likely to be found in the interior of a globular protein due to its hydrophobic side chain?
A
Glutamate
B
Serine
C
Leucine
D
Lysine
Verified step by step guidance1
Understand the structure of a globular protein: Globular proteins are compact, spherical proteins where hydrophobic amino acids tend to be buried in the interior to avoid contact with water, while hydrophilic amino acids are often found on the surface interacting with the aqueous environment.
Review the properties of the amino acids listed: Hydrophobic amino acids have nonpolar side chains that do not interact favorably with water, while hydrophilic amino acids have polar or charged side chains that interact well with water.
Analyze the side chains of the given amino acids: Glutamate has a negatively charged polar side chain, Serine has a polar hydroxyl group, Lysine has a positively charged polar side chain, and Leucine has a nonpolar, hydrophobic aliphatic side chain.
Determine which amino acid is most likely to be found in the interior of the protein: Since Leucine has a hydrophobic side chain, it is most likely to be buried in the interior of the globular protein to minimize interaction with water.
Conclude that the correct answer is Leucine based on its hydrophobic nature and the tendency of globular proteins to sequester hydrophobic residues in their interior.
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