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Multiple Choice
Which of the following amino acids is classified as a basic (positively charged) amino acid at physiological pH?
A
Serine
B
Leucine
C
Lysine
D
Glutamic acid
Verified step by step guidance
1
Understand the classification of amino acids: Amino acids are categorized based on the properties of their side chains (R groups). At physiological pH (~7.4), amino acids can be neutral, acidic (negatively charged), or basic (positively charged). Basic amino acids have side chains that are positively charged due to protonation.
Identify the basic amino acids: The three amino acids classified as basic at physiological pH are lysine, arginine, and histidine. Their side chains contain functional groups that can accept protons, making them positively charged.
Analyze the options provided: Serine has a hydroxyl (-OH) group in its side chain, making it polar but uncharged. Leucine has a hydrophobic aliphatic side chain, making it neutral. Glutamic acid has a carboxylic acid group in its side chain, which is negatively charged at physiological pH. Lysine has an amino group (-NH3+) in its side chain, which is positively charged at physiological pH.
Determine the correct answer: Based on the analysis, lysine is the only amino acid in the list that is classified as basic (positively charged) at physiological pH.
Conclude the reasoning: Lysine's positively charged amino group in its side chain makes it a basic amino acid, distinguishing it from the other options provided.