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Multiple Choice
How many distinct aminoacyl-tRNA synthetase enzymes must be present in cells to properly synthesize proteins?
A
20
B
61
C
64
D
1
Verified step by step guidance
1
Understand the role of aminoacyl-tRNA synthetase enzymes: These enzymes are responsible for attaching the correct amino acid to its corresponding tRNA molecule, a process called aminoacylation. This ensures that the genetic code is accurately translated during protein synthesis.
Recall the number of standard amino acids: There are 20 standard amino acids used in protein synthesis. Each amino acid must be matched with its specific tRNA molecule by a dedicated enzyme.
Recognize the specificity of aminoacyl-tRNA synthetases: Each aminoacyl-tRNA synthetase enzyme is specific to one amino acid and its corresponding tRNA(s). This means there must be one enzyme for each amino acid.
Consider the genetic code and codons: While there are 64 possible codons in the genetic code, only 61 codons code for amino acids (the remaining 3 are stop codons). However, the number of synthetases is determined by the number of amino acids, not the number of codons.
Conclude that the number of distinct aminoacyl-tRNA synthetase enzymes corresponds to the number of standard amino acids, which is 20. This ensures that all amino acids are properly attached to their respective tRNAs for protein synthesis.