Multiple Choice
In order to reuse an enzyme after the conclusion of an enzyme-catalyzed reaction, which of the following must be true about the enzyme?
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7. Enzyme Inhibition and Regulation
Enzyme Inhibition
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Which type of irreversible inhibitor is also known as a substrate analog?
A
Noncompetitive inhibitor
B
Competitive inhibitor
C
Suicide inhibitor
D
Allosteric inhibitor
Verified step by step guidance1
Understand the concept of irreversible inhibitors: These inhibitors bind covalently to the enzyme, permanently inactivating it. Unlike reversible inhibitors, they cannot be displaced by dilution or removal of the inhibitor.
Learn about suicide inhibitors: Suicide inhibitors are a specific type of irreversible inhibitor that mimic the enzyme's natural substrate. They bind to the active site and undergo a reaction, leading to the formation of a covalent bond with the enzyme, effectively inactivating it.
Compare suicide inhibitors to substrate analogs: Substrate analogs are molecules that resemble the enzyme's natural substrate. Suicide inhibitors are considered substrate analogs because they mimic the substrate's structure and interact with the enzyme in a similar way.
Differentiate suicide inhibitors from other types of inhibitors: Noncompetitive inhibitors bind to a site other than the active site and do not resemble the substrate. Competitive inhibitors resemble the substrate but do not irreversibly bind to the enzyme. Allosteric inhibitors bind to regulatory sites and modulate enzyme activity without resembling the substrate.
Conclude that suicide inhibitors are substrate analogs because they mimic the substrate and irreversibly bind to the enzyme, distinguishing them from other types of inhibitors listed in the problem.
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