Multiple Choice
For a protein to be an integral membrane protein, it would have to be _____.
10. Lipids
Integral Membrane Proteins
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In the hydrophobic environment of a membrane, the α-helix of a protein folds such that the outer surfaces contain mostly _________________ amino acids, while _________________ amino acids are mostly buried on the inside.
A
Non-polar; Hydrophobic.
B
Polar; Hydrophilic.
C
Hydrophobic; Non-polar.
D
Polar; Hydrophobic.
E
Non-polar; Hydrophilic.
Verified step by step guidance1
Understand the structure of an α-helix in a protein: It is a common secondary structure characterized by a right-handed coil where the backbone is on the inside and the side chains extend outward.
Recognize the environment: In a hydrophobic environment, such as a membrane, the protein structure will adapt to minimize unfavorable interactions with the surrounding environment.
Identify the nature of amino acids: Non-polar amino acids are hydrophobic and tend to be found on the outer surfaces of the α-helix in a membrane environment to interact with the lipid bilayer.
Consider the interior of the α-helix: Polar or hydrophilic amino acids are typically buried inside the helix to avoid contact with the hydrophobic environment.
Conclude the arrangement: In a membrane, the α-helix will have non-polar (hydrophobic) amino acids on the outside and polar (hydrophilic) amino acids on the inside, making option 'e' (Non-polar; Hydrophilic) the correct choice.
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