Step 4: Eliminate the other options. Polar amino acids have side chains with groups that can form hydrogen bonds (e.g., hydroxyl, amide, or sulfhydryl groups). Acidic amino acids have negatively charged side chains at physiological pH (e.g., aspartate and glutamate), and basic amino acids have positively charged side chains (e.g., lysine, arginine, and histidine). Alanine and leucine do not fit these descriptions.