Multiple Choice
In the context of nucleic acids and cellular metabolism, ATP is classified as which of the following?
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1. Introduction to Biochemistry
Nucleic Acids
Multiple Choice
In nucleic acid synthesis, which enzyme catalyzes formation of phosphodiester bonds to join nucleotides into a growing DNA strand?
A
Primase
B
DNA ligase
C
DNA polymerase
D
Helicase
Verified step by step guidance1
Understand the role of each enzyme listed in the problem: Primase, DNA ligase, DNA polymerase, and Helicase.
Recall that phosphodiester bonds are the covalent bonds that link the 3' hydroxyl group of one nucleotide to the 5' phosphate group of the next nucleotide in a DNA strand.
Identify which enzyme is responsible for catalyzing the formation of these phosphodiester bonds during the elongation of a new DNA strand.
Note that DNA polymerase adds nucleotides to the growing DNA strand by forming phosphodiester bonds, using the template strand to guide complementary base pairing.
Confirm that the other enzymes have different functions: Primase synthesizes RNA primers, DNA ligase joins Okazaki fragments by sealing nicks, and Helicase unwinds the DNA double helix.
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