Join thousands of students who trust us to help them ace their exams!Watch the first video
Multiple Choice
Which of the following amino acids contains a positively charged (basic) side chain at physiological pH?
A
Serine
B
Glutamine
C
Leucine
D
Lysine
Verified step by step guidance
1
Step 1: Understand the question. The problem asks which amino acid has a positively charged (basic) side chain at physiological pH (approximately 7.4). This requires knowledge of amino acid structures and their behavior at physiological pH.
Step 2: Recall the classification of amino acids. Amino acids can be grouped based on the properties of their side chains: polar, nonpolar, acidic, and basic. Basic amino acids have side chains that are positively charged at physiological pH.
Step 3: Analyze the given options. Serine has a polar, uncharged side chain (-CH2OH). Glutamine has a polar, uncharged side chain (-CH2CONH2). Leucine has a nonpolar, hydrophobic side chain (-CH2CH(CH3)2). None of these are basic.
Step 4: Examine Lysine. Lysine has a side chain containing an amino group (-CH2CH2CH2CH2NH2) that is protonated at physiological pH, making it positively charged and basic.
Step 5: Conclude that Lysine is the correct answer because its side chain is positively charged at physiological pH, unlike the other options provided.