Multiple Choice
When epinephrine binds to a(n) ________________ receptor, _______ is activated, causing an increase in the cellular concentration of ________________.
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12. Biosignaling
Phosphoinositide GPCR Signaling
Multiple Choice
Which of the following are secondary messengers produced in the PSP pathway?
A
cGMP & K+.
B
IP2 & IP3.
C
IP3 & DAG.
D
DAG & cAMP.
Verified step by step guidance1
Understand the concept of secondary messengers: Secondary messengers are molecules that relay signals received at receptors on the cell surface to target molecules inside the cell, in response to an extracellular signal.
Identify the common secondary messengers: Some well-known secondary messengers include cyclic AMP (cAMP), cyclic GMP (cGMP), inositol trisphosphate (IP3), diacylglycerol (DAG), and calcium ions (Ca2+).
Analyze the PSP pathway: The Phosphatidylinositol 4,5-bisphosphate (PIP2) pathway involves the enzyme phospholipase C (PLC) which cleaves PIP2 into two secondary messengers: inositol trisphosphate (IP3) and diacylglycerol (DAG).
Evaluate the options given: Compare each option with the known secondary messengers in the PSP pathway. The correct secondary messengers produced in this pathway are IP3 and DAG.
Conclude with the correct answer: Based on the analysis, the correct secondary messengers produced in the PSP pathway are IP3 and DAG, as they are directly involved in the signaling cascade initiated by the cleavage of PIP2.
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